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Presenters: Georges Favre (LNE), Caterina Minelli (NPL)
09.04.2024
14:00 – 16:00 CEST
Metrology, method validation, standardisation… they are concepts that might sound complicated, but are essential in analytical sciences, since they strongly support the development of innovative products such as advanced materials or nanomedicine.
This Webinar aims to provide experienced researchers, but also young researchers, PhD students, and lab technicians the basis of metrology and standardisation. Information will be shared on important concepts (reference materials, SOPs, inter-laboratory comparisons…) and associated existing databases. The pathway to follow from the development of a standard operating procedure (SOPs) to a standard test method will be explained together with the role of national metrology institutes, metrology committees, standardisation bodies (ISO, ASM, CEN, VAMAS), and specific entities (e.g. the OECD, ICH, and EDQM).
Finally, two different cases of the maturity of this process will be described to illustrate the path towards validated and recognized methods in relation to nanomedicine and advanced materials. This knowledge is invaluable for increasing the impact of the protocols you develop beyond the academic community, and for keeping abreast of new standards and reference materials on the horizon.
Outlook:
BASICS OF (DEFINITIONS):
LANDSCAPE & OPPORTUNITIES
AN EXAMPLAR JOURNEY FROM NEED TO STANDARD
EXAMPLES FOR ADVANCED MATERIALS – WHAT’S THE ALTERNATIVE FOR LESS MATURE CASES?
Presenters: see the programme below
11.04.2024
14:00 – 16:00 CEST
Regulatory safety testing of chemicals and materials is still mainly focused on animal testing. A huge number of New Approach Methodologies (NAMs) to replace or reduce animal testing have been scientifically developed within the last years. Their regulatory use, however, is still limited. A possible way to include NAMs into regulatory testing may be found in Adverse Outcome Pathways (AOPs). We will present what AOPs are, how they can be developed and established at OECD. The AOP for pulmonary fibrosis and the AOP on acute lung toxicity will serve as examples for the development of nanomaterial-relevant AOPs. We will discuss the implementation of AOPs into regulatory testing and hurdles.
Topics of the Webinar:
Overview of AOPs and their development
The AOP for Pulmonary Fibrosis: The first nanomaterial-relevant AOP en-dorsed
An AOP for acute lung toxicity including a NAM
Applicability of AOPs in (regulatory) hazard assessment
Agenda:
Moderator: Steffi Friedrichs
(technical) support: Elisabeth Heunisch
Time | Topic | Speaker |
2:00 – 2:10 | Welcome by MACRAMÉ and nanoPASS | Steffi Friedrichs (AIST) |
2:10 – 2:30 | Overview of AOPs and their development | Nathalie Delrue (OECD) |
2:30 – 2:50 | What is next for AOP173/AOP33? | Sabina Halappanavar (Health Canada) |
2:50 – 3:10 | An AOP for acute lung toxicity including a NAM | Jorid Birkelund Sørli (NRCWE) |
3:10 – 3:30 | Applicability of AOPs in (regulatory) hazard assessment | Qasim Chaudhry (University of Chester) |
3:30 – 3:55 | Q & A and Discussions | Blanca Suarez Merino (NIA) |
3:55 – 4:00 | Closing the meeting | Sean Kelly (NIA) |
